Topic: brain-wide neuronal activity

The brain is efficient to categorize continuous sensory inputs into discrete perceptions to aid efficient action. The brain-wide neural mechanism underlying this sensory-to-categorical transformation remains elusive. Here we recorded brain-wide neuronal activity by Neuropixels probes in mice performing a two-alternative forced choice (2AFC) odor categorization task, using different combinations of odor mixtures. Mixtures of two pure odors were delivered at different ratios, and the left or right lick decision after a delay period should be based on the category defined by the dominant odor. Mi

Sleep is an essential process observed throughout the animal kingdom, and it is important for memory consolidation. Coordinated neuronal activity occurs during sleep, characterized by distinct events across different sleep states. Non-rapid eye movement (NREM) sleep features slow oscillations, delta waves, thalamocortical spindles and hippocampal sharp waves-ripples, while REM sleep is dominated by hippocampal theta oscillations and ponto-geniculo-occipital (PGO) waves, or pontine waves (“P-waves”) in rodents. Even though their origin from mesopontine cholinergic and glutamatergic nuclei is kn