Topic: Bursting neurons

High-density electrophysiological probes have substantially increased the spatial resolution and scale of neural recordings. Popular spike sorting algorithms, e.g. Kilosort (Pachitariu et al. 2016), SpyKING CIRCUS, etc., use waveform template matching to isolate single units from the large-scale recordings, but these algorithms make numerous errors which often require hours of manual curation to correct. Bursting neurons pose an additional challenge in spike-sorting: the shape and amplitude of a neuron’s waveform can change significantly over the course of a burst. Thus, waveform shape- based

The subiculum is one of the most important brain structure in the hippocampal formation which has an essential role in forwarding the hippocampal information to different cortical and subcortical regions. Pyramidal cells are the principal cell type in the subiculum and based on their firing dynamics, they can be divided into regular and bursting phenotypes. Previously, functional characterization of these cells was mainly performed by using conventional electrophysiological methods (current steps). However, our research group uses advanced methods (dynamic clamp) to expose neurons to physiolog