Studying acute ischemic stroke (AIS) clots for novel stroke biomarker discovery
Nazan Guner Sak, Cansu Sahin, Wenyi Liu, Alice Giraud, Pierluca Messina, Franz Bozsak, Jean Darcourt, Federico Sacchetti, Jorge Pagola, Jesus Juega, Laurent Spelle, Vanessa Chalumeau, Ivan Vukasinovic, Marc Ribo, Nobuyuki Sakai, Christophe Cognard, Karen Doyle · FENS Forum 2024
Acute Ischemic Stroke (AIS) is a major cause of death and disability worldwide. Mechanical thrombectomy to remove clots from cerebral vasculature represents a unique opportunity to study characteristics and biological patterns of stroke pathophysiology. There is marked heterogeneity in clots and great interest in etiological biomarkers for novel therapeutic approaches/stroke prevention strategies. We investigated expression of prototypic marker of inflammation C-reactive protein (CRP) and coagulation factor thrombin in AIS clots of different etiologies. Clots from Clotbase International regist