Topic: C1QL1

Purkinje cells (PCs) are known to express both GluK1 and GluK4 kainate receptor (KAR) subunits, but the exact role of KARs in synaptic information transfer to PCs is unknown. In this study, we discovered that climbing fiber (CF) to PC synapses contain heteromeric GluK1/GluK4 synaptic KARs. Genetic deletion of Grik4, which encodes for GluK4 subunits, resulted in the lack of synaptic but not extrasynaptic KARs, while deletion of Grik1 (GluK1 subunits) eliminated both synaptic and extrasynaptic KARs. Surprisingly, the absence of synaptic KARs led to a significant reduction in the EPSC component m

The cerebellum is an area of the brain involved in sensory-motor adaptation, movement coordination and higher cognitive processes. Within the cerebellar cortex, mossy fibres (MFs) convey sensorimotor input to a dense layer of granule cells (GrCs). GrCs relay this information through parallel fibre (PF) projections that synapse with Purkinje cells (PCs), the sole output of the cerebellar cortex, and molecular layer interneurons (MLI), which provide feedforward inhibition of PCs. Accordingly, PCs compute incoming sensorimotor patterns and send inhibitory outputs that rapidly adjust motor movemen