Topic: C57BL/6J

Investigation of social behavior in mice is increasingly relevant to understand associated brain circuits and thereby develop treatments for psychiatric symptoms such as social withdrawal. Importantly, a data-driven description of social behavior and how the behavioral repertoire of mice differs in solitary vs. social context is lacking. Here, we aim to identify, in a data-driven manner, recurring behavioral patterns (“syllables”) that are unique to social and solitary contexts.We recorded videos of male C57BL/6j mice, in two epochs of 90 minutes duration, either in a social context (n=4) or i

Aims: Sign-tracking (ST) behavior is a phenotype characterized by attraction to a reward-associated stimulus due to incentive salience attribution and it’s considered an endophenotype of vulnerability to drug addiction. Such phenotype is dependent on Dopamine (DA) transmission within the Nucleus Accumbens core (NACc), as DA suppression prevents both its development and expression. However, previous studies suggested the hypothesis that ST behavior can be dependent on different neural mechanisms in two inbred strains of C57BL/6J (C57) and DBA/2J (DBA) mice, which have known differences in their

The effect of living conditions on the physiology, behaviour and stress of laboratory animals is still being discussed. There are conflicting findings regarding individually ventilated cages(IVC). This study aims to explore the effects of three distinct cage setups and to examine the differences in the impacts of IVC cages, classical cages and classical cages with varying mouse populations. Thirty male C57BL/6J strain mice were split into three groups:IVC, classical small(CC500) and big(CC800) with a floor size of 500 and 800 cm2,respectively. From birth until six months of age, the mice were

The Nrxn1 +/- mouse is a novel strain (Lu H, et al. 2023. Cell Reports. 42:112714), which has not previously been studied for learning and memory performance. Our experiment trained 6-9 month-old male and female Nrxn1+/- and Nrxn1+/+ wildtype (C57BL/6J) mice for odour discrimination learning in an operant olfactometer with a sucrose reward for responding (licking) to the CS+ odour and no reward for responding to the CS- odour. Once the mice had met the criterion of 85% correct, they were tested in a reversal learning paradigm. The total errors made by the Nrxn1+/- mice and wildtype mice were a

Early stress episodes affect brain development and is related to increased risk of developing stress-induced depression in adulthood. However, little is known about the sexual differences in this process. Our goal is to study how stress in different developmental periods affects depression-like behaviours in male and female mice. For this purpose, four experimental groups of both male and female mice of strain C57BL/6J were used: control (C) Juvenile (JE), adult (AE), and double stress JE+AE (DE).Depression-like behaviours were evaluated in the adult period. Nest building test was used to asse