Topic: CA1 activity

Hippocampal place-cell activity is thought to support the formation of a cognitive map that allows the association of an event to its spatial context. It has long been thought that within familiar spatial contexts, such neuronal representations should be stable over time, and that individual place cells should retain their coding properties. However, recent findings have demonstrated that hippocampal codes gradually change over timescales of minutes to weeks. Several studies have suggested that this gradual drift in the ensemble activity patterns of hippocampal neurons could serve as a mechani

Episodic memory (EM), the remembrance of an event with spatiotemporal (what-where-when) information relies on the hippocampus (HP) and the entorhinal cortex (EC). The superficial layers of the EC provide the primary input to the HP via the perforant path, so we use a mouse line capable of expressing chemogenetic inhibitors in a particular set of projection neurons of EC Layer II (EC stellate and fan cells) to examine the precise role played by EC inputs in different forms of episodic memory. For this we employ an episodic memory task with both olfactory and spatial twin variants. Both are iden