Topic: CA1 hippocampal region

Maintaining Ca2+ homeostasis is extremely important for the nervous system. Fluctuations in extracellular Ca2+ concentration ([Ca2+]e) are very frequent, both under physiological and pathological conditions. Among extracellular calcium sensors, the Calcium-Sensing Receptor (CaSR), is a G-protein coupled receptor activated by [Ca2+]e and is ubiquitously expressed in the body. The CaSR is expressed in brain regions involved in memory and cognition, however the mechanisms by which CaSR regulates neuronal function remain unexplored.We therefore studied how CaSR regulates neuronal excitability in t

Schizophrenia is a neuropsychiatric syndrome that affects around 1% of the world population. It is characterized by psychotic or positive symptoms, negative symptoms and cognitive deficits. Currently, antipsychotic treatments can help to manage psychotic symptoms in acute episodes of schizophrenia. However, there is an unmet medical need for the treatment of those cognitive symptoms that appear since the premorbid phase and affect almost 98% of patients. Despite the identification of some molecular pathways that are impaired in schizophrenia, little is known about the possible contribution tha