Topic: CA3 pyramidal neurons

Epilepsy is a common comorbidity of mTORopathies such a Tuberous Sclerosis Complex (TSC) and mTOR hyperactivity-associated Fragile X Syndrome (FXS), both characterized by severe cognitive dysfunctions. On the other hand, medial Temporal Lobe Epilepsy (mTLE) is associated with mTOR hyperactivity within the hippocampal formation and cognitive deficits, particularly pertaining to pattern separation and episodic memory. The hippocampal dentate gyrus (DG) subregion is crucial for gating the flow and separating the patterns of cortical information inputs, transmitting them via DG granule cell mossy

CA3 pyramidal neurons (PNs) in the hippocampus are connected by recurrent collateral synapses, forming the largest auto-associative network in the mammalian brain. How the recurrent connectivity between CA3 PNs is established during development remains unclear. To address this question, we made simultaneous patch-clamp recordings of up to eight CA3 PNs in the mouse hippocampus (7600 tested connections in total). Average connectivity in the mouse hippocampus was down-regulated during development, with apparent average connection probability values of 3.63% (P7–8), 2.41% (P18–22), and 0.94% (P45

Denervation of brain regions is a common aspect of neurological diseases caused by traumatic brain injury or demyelination. Nevertheless, the mechanisms underlying lesion-induced reorganization of the affected brain regions is a matter of ongoing investigation.Using an entorhinal cortex lesion in mouse organotypic entorhino-hippocampal tissue cultures, we investigated denervation-induced adaptations in dentate granule cells, CA3 pyramidal neurons and their monosynaptic connection – the mossy fiber synapse. For functional and structural analysis of these cells, we employed single and paired who

To comprehend the brain’s dynamic physiology, we must understand the mechanisms underlying neuronal excitability, crucial for neurons’ electrical activation during synaptic communication. Of particular interest is controlled potassium current leakage via two-pore domain potassium channels which finely modulate the intrinsic excitability of neurons. TRESK, the latest discovered channel of the K2P family, has a well-characterized pivotal role in nociception. Intriguingly, it also exhibits widespread expression throughout central nervous system, yet its function within the brain has remained unex