Calcineurin

The functioning of a synapse depends on its accessibility to proteins and, thus, on the localization of protein sources along the dendrite (Westenbroek 2009, Vacher et al. 2008). Therefore, the behaviour of the synapse highly depends on the availability of proteins and ion channels and any perturbation in the localization and availability of these components would lead to a dysfunction of the synapse. Hence, understanding the localization and distribution of ion channels and proteins in the dendrite in relation to the synapse is crucial. Using super-resolution microscopy, Helm et al., 2021 der

…of the regulatory CaNB1 subunit of calcineurin in astrocytes could mitigate AD-related memory deficits, neuropathology and neuroinflammation.We have generated two, acute and chronic, AD mouse models with astrocytic CaNB1 deletion (ACN-KO). In the acute one we evaluated the ability of β-amyloid oligomers (AβO

Site-specific synaptic plasticity modifying the strength of a particular, individual synapse is critical to cognitive functions such as memory and learning (Kastellakis et al., 2019; Tazerart et al., 2020). This specificity coexists with the experimental observation that the dendrite-wide spine sizes and weights follow a surprisingly stable, lognormal-like distribution (Hasan et al. 2020; Eggl et al., 2023). How synaptic plasticity can be specific, yet the global synapse distribution stable, is an open question that has motivated several recent studies (Kirschner et al., 2019; Eggl et al., 202