Topic: calcium signalling

Noradrenaline is released via volume transmission from axons originating in the locus coeruleus and released into the parenchyma to be detected by both neurons and astrocytes. Noradrenergic α-1 receptors are Gq-coupled receptors that induce intracellular calcium release from the endoplasmic reticulum as a key pathway for astrocyte calcium signalling. Due to interactions between astrocytes and synapses including their known roles in structural isolation of synapses, metabolic support, potassium buffering and gliotransmitter release, fluctuations of intracellular calcium in astrocytes can influe

As evidence for the NMDA receptor hypofunction theory of schizophrenia grows, more attention is being paid to restoring correct glutamatergic signalling as a therapy option leading to development of novel antipsychotics. The ESCRT proteins groups are involved in sorting ubiquitinated membrane receptors to lysosomes, which is a key method for reducing cell surface receptor signalling. The research illustrates the effect of knocking down and overexpression of TSG101 and VPS4a genes on the function of ESCRTs machinery and the expression of NMDA receptors. The average number of NMDA receptors on t

Calmodulin (CaM) is one of the key neuronal calcium binding proteins that is essential in calcium signalling (Xia and Storm, 2005; https://doi.org/10.1038/nrn1647). Reflecting its importance, there are many different computational kinetic calcium-CaM models (Heil et al., 2018; https://doi.org/10.1101/254094). However, there has been no quantitative comparison and evaluation of these models, with some publications not reporting their training and validation performance. Moreover, there is no comparison on a common benchmark data set as is common practice in other modeling domains.We quantitativ