Topic: cAMP signalling

Age-related decline in brain glucose utilization might stem from noradrenergic system dysfunction, which governs brain metabolism and could play a role in age-related cognitive decline. Noradrenaline released from these neurons triggers intracellular Ca2+ and cAMP signals in astrocytes, facilitating glucose uptake, glycogen degradation, and aerobic glycolysis, producing lactate as an end-product. During heightened brain activity, lactate is transferred from astrocytes to neurons to serve as fuel. The extent to which noradrenergic regulation of brain cell metabolism is impaired in aged brains a

Sleep deprivation (SD) detrimentally affects hippocampal-dependent memories, notably spatial and fear memories. However, its effect on social recognition memory — crucial for identifying conspecifics, remains unexplored. To address this, we developed a novel protocol to study the effects of SD on long-term social recognition memory (SRM) in adult male C57BL/6J mice. Our study revealed that 6 hours of SD, following a socialization trial, caused amnesia when SRM was assessed 24 hours later.Next, we investigated whether SD causes permanent loss or suboptimal storage of SRM. We employed mouse mode