Topic: capillary density

The African naked mole rat (NMR) is an extremely long-lived species compared to its body size and can reach above 30 years of age. The NMR show unique adaptations to resist damage to the brain. They can survive up to 20 minutes of complete anoxia [1] and express high levels of amyloid-β without developing amyloid plaques [2]. Our aim is to understand if altered lipid metabolism through regulation of lipid droplets (LDs) in brain cells is one of the NMRs intrinsic adaptations, giving them their long-lived phenotype and resistance to neurological damage. Immunohistochemistry was performed on bra

Aims: Parkinson's disease (PD), a chronic neurological disorder affecting motor functions, is characterized by damage to dopaminergic neurons in the substantia nigra pars compacta (SNc). This study investigates the therapeutic properties of bacterial melanin (BM), known for enhancing brain trophic effects, inhibiting inflammation, and mitigating gliosis—a key aspect in PD development.Methods: To assess rat brain morpho-functional states, we conducted histochemical and morphometric studies on SNc cellular structures post-rotenone intoxication and under BM influence. Experiments involved intact