Differential sensitivity and molecular responses of malignant cells derived from neuronal and glial cells to ER and proteasome stress
Peter Racay, Ivana Pilchova, Katarina Dibdiakova, Jaroslava Guzikova, Monika Liskova, Lubos Hudak, Jozef Hatok · FENS Forum 2024
Proliferation of malignant cell also depends on high rate of protein synthesis that increases demands on protein quality control mechanisms. Quality of intracellular proteins are controlled at the level of both endoplasmic reticulum (ER) and 26S proteasome. Disturbances in the functions of either ER or proteasome are associated with particular stress responses. The cellular response to ER stress involves translation inhibition, expression of ER chaperones and degradation of aberrant protein. Elevated expression of HSP70 that binds aberrant proteins or supports their translocation to lysosomes
ePoster · Neuroscience