Topic: caudate

The neuronal population of the striatum is primarily composed of medium spiny projecting neurons (MSNs), with only a small percentage (around 5% in mice) being locally projecting neurons or interneurons. Despite their low numbers, interneurons play a crucial role in regulating the flow of information within the striatum and to other brain nuclei, thereby having significant implications for motor control and cognition.We recently identified one of the most abundant populations of GABAergic interneurons in the striatum that express Pthlh and varying levels of Pvalb, which correlates with intrins

Ageing is accompanied by changes in brain intrinsic functional connectivity (FC) and cognitive decline. Although the connection between resilience and cognitive performance in older adults has been explored, the neural mechanisms underlying this relationship remain elusive. Processing speed is vital for daily functioning and independence among older adults Specifically, how resilience impacts intrinsic FC within brain networks and individuals' processing speed has yet to be thoroughly addressed. To uncover this question, we recruited 102 healthy ageing individuals aged 60-79 to complete a rest