Topic: CD40

Chronic neuroinflammation, associated with central nervous system (CNS) pathologies, involves persistent microglial activation. Misfolded proteins in Alzheimer’s disease and mechanical CNS lesions initiate prolonged immune responses, contributing to neuronal damage. Recent literature suggests the induction of controlled immune modulation to foster neuro-restoration. We propose the use of protein kinase C (PKC) activators to modulate CNS innate immune cells (i.e., microglia) for regenerative therapeutic approaches. Therefore, we examined the molecular and functional effect of PKC activators (Pr

The activity of microglia, the resident immune cells of the central nervous system (CNS), is controlled by various neurotransmitters and modulators. For instance, monoamines such as serotonin (5-HT) and norepinephrine (NE), have been reported to modulate the physiological functions of microglia. However, altered concentrations of monoamines have been observed in pathologies of the CNS, such as Alzheimer's disease or major depressive disorder. Remarkably, changes in monoamine levels happen in synchrony with altered microglial functions during CNS diseases. Thus, a reduced immune modulation thro