Cell migration

…sessions address morphogenesis and cell migration; materials sessions consider elastomers, soft actuators and damping. Ferroelectric nematics and developments in augmented and virtual reality connect fundamental discoveries with device applications. Theory, numerical modelling and experiments will bring physicists, chemists, biologists and engineers together to compare mechanisms across these areas. Attendance applications are reviewed and capacity may fi

…actin filament dynamics essential for cell migration and growth, controlling both formin- and Arp2/3 complex-dependent actin assembly pathways.

…Transferred into cell culture, neurons follow the same homeostatic principles. They migrate and regrow neurites to establish synaptic connectivity and spontaneous network activity. Despite of homeostatic regulation, the resulting network structure and activity dynamics exhibit considerable variability across and within studi

FoxP genes have been linked to autism spectrum disorder (ASD), a neurodevelopmental disorder that is associated with aberrant connectivity of neural circuits. There is evidence that mutations in FoxP genes lead to impaired cognition, speech, and motor abilities. The goal of our work is to elucidate and characterize distinct molecular mechanisms with which FoxP genes orchestrate neural circuit formation. As a first step, we characterized the temporal and spatial expression pattern of the FoxP transcription factors. To study their impact on neural circuit assembly, we are using the chicken embry

…was excised and bridged using the decellularized nerve. Then, rats were randomly divided into MeCbl treated and saline treated groups. At postoperative 7 days, nerves were harvested and evaluated for immunohistochemistry. For in vitro experiments, scratch assay, and tube formation assay were evaluated in the presence or absence of MeCbl using human umbilical vein endothelial cells. Additi

The activity of microglia, the resident immune cells of the central nervous system (CNS), is controlled by various neurotransmitters and modulators. For instance, monoamines such as serotonin (5-HT) and norepinephrine (NE), have been reported to modulate the physiological functions of microglia. However, altered concentrations of monoamines have been observed in pathologies of the CNS, such as Alzheimer's disease or major depressive disorder. Remarkably, changes in monoamine levels happen in synchrony with altered microglial functions during CNS diseases. Thus, a reduced immune modulation thro

CHARGE syndrome (CS) is a rare genetic disease, mainly due to mutations in the chromatin remodeler gene CHD7 and characterized by multiple neuronal dysfunctions and malformations of neural-crest derived organs, for which no pharmacological treatments are available. CS high phenotypic variability could be explained by mutations in genes with an epistatic relationship to CHD7, that may alter the expressivity of disease traits. In this context, recent evidence revealed that genes encoding semaphorins (SEMA) and their receptors might be good candidates as CHD7 genetic interactors. Thus, we generat