Topic: center-out reaching task

How does the motor cortex (MC) achieve generalizable and purposeful movements from the complex non-linear musculoskeletal system? This understanding can help us uncover how does the cortical activity relates to the movement. To elucidate this relationship, we build a model of the MC with realistic properties. To mimic the recurrent connections between cortical neurons, we use recurrent neural networks (RNNs) to model the MC. The MC model receives sensory feedback and delivers muscle excitations to anatomically accurate musculoskeletal models to produce experimentally observed movements. The se

By causally mapping neural activity to behavior [1], Brain-Computer Interfaces (BCI) offer a means to study the dynamics of sensorimotor learning. Here, we combine computational modeling and data analysis to study the neural learning algorithm [2] monkeys use to adapt to a changed output mapping in a center-out reaching task. We exploit that the mapping from neural space (ca. 100 dimensions) to the 2D cursor position is a credit assignment problem [3] that is underconstrained, because changes along a large number of output-null dimensions do not influence the behavioral output. We hypothesized