Topic: centrolateral amygdala

Object-directed behaviors are crucial for survival in natural environments. Although recent interest has focused on the encoding of objects and the representation of egocentric spatial relationships within the lateral entorhinal cortex (LEC), the downstream circuitry and mechanisms orchestrating these behaviors remain elusive. Similarly, significant progress has been made in uncovering amygdala circuit-level mechanisms for defensive and appetitive behaviors, yet integrating spatial object information within specific amygdala circuits remains a puzzle. To address these gaps, we unveil a com

Copy number variation in genes associated with glutamatergic transmission have emerged as significant factor in various mental and neurodegenerative disorders. Recent studies have shed light on the role of the GRIK4 gene, which encodes the GluK4 subunit of kainate receptors, in conditions such as autism and schizophrenia. Specifically, de novo duplications of the GRIK4 have been identified in individuals with autism. Overexpression of the Grik4 gene in a mouse model (GluK4over) leads to social deficits, anxiety and depression and has a significant impact on amygdala neuronal excitability, caus