Topic: cerebral infarction

Platelet activation plays a crucial role in cerebral vascular diseases (CVDs) such as ischemic stroke, making the suppression of platelet function a promising strategy for mitigating CVDs. Ginkgetin (GK), from Ginkgo biloba L, known for its diverse bioactivities, remains largely unexplored in modulating platelet activity. This study systematically investigated GK's effects on human platelets, aiming to understand its therapeutic potential in alleviating CVDs. The experiments examined GK's effects on human platelets, analyzing aggregation, secretion, calcium mobilization, and thromboxane genera

The crosstalk between the nervous and immune systems has gained increasing attention for its emerging role in neurological diseases. Radiation-induced brain injury (RIBI) remains the most common medical complication of cranial radiotherapy, and its pathological mechanisms have yet to be elucidated. Here, using singlecell RNA and T cell receptor sequencing, we found infiltration and clonal expansion of CD8+ T lymphocytes in the lesioned brain tissues of RIBI patients. Furthermore, by strategies of genetic or pharmacologic interruption, we identified a chemotactic action of microglia-derived CCL