Cerebral vasculature

…thrombectomy to remove clots from cerebral vasculature represents a unique opportunity to study characteristics and biological patterns of stroke pathophysiology. There is marked heterogeneity in clots and great interest in etiological biomarkers for novel therapeutic approaches/stroke prevention strategies. We investigated expression of prototypic marker of inflammation C-reactive protein (CRP) and coagulation factor thrombin in AIS clots of different etiologies. Clots from Clotbase International regist

The dynamic role of neuroinflammation in diverse neurological disorders is still poorly characterized but could represent a promising avenue for therapeutic interventions. Here we aimed at characterizing brain-wide response of microglia to ischemic stroke in mouse. Microglia, the frontline responders to ischemic stroke, is known to exhibit diverse morphology and gene expression in response to diverse stimuli and depending on tissue context, yet how their activation signature propagates across the brain in response to local stroke has remained unknown. Here we established a whole-brain three-di