Alzheimer-like β-amyloid plaques in the brain of a striped dolphin
Carlotta Tessarolo, Alessandra Favole, Camilla Testori, Virginia Mattioda, Marina Gallo, Carla Grattarola, Ksenia Orekhova, Tiziana Avanzato, Barbara Iulini, Antonio Fernandez, Simona Sacchini, Paula Alonso-Almorox, Fulvio Garibaldi, Cristina Casalone, Cristiano Corona, Federica Giorda · FENS Forum 2024
The main reason Alzheimer's disease (AD) is thought to be a human illness is the lack of reliable animal models for spontaneous disease. The complexity and comparability of the brain, along with age-related problems, present challenges for experimental animal models. Recently, Amyloid-β (Aβ) plaques (APs) and phosphorylated tau (ptau) changes in neurons and neuropil were observed in different mammal species, with very few descriptions in cetaceans. This study describes Aβ deposition in the brain tissue of a female striped dolphin (Stenella coeruleoalba) stranded in the Ligurian coast of the
ePoster · Neuroscience