Topic: chemokines

Consequences of children brain exposure to radiation (doses ≤ 2 Gy) are not clearly established. The advent of computed tomography scans use for head exploration as well as a recent increase in the use of interventional neuroradiology in pediatrics raised the need to improve our knowledge of these effects. To understand how irradiation may affect the developing brain, we previously developed models of either whole brain or hippocampal dorsal dentate gyrus irradiation in ten-day-old male mice (doses ≤ 2 Gy) and demonstrated some alterations in adult mice behavior and in hippocampal neurogenesis

Peritonitis poses a serious medical challenge due to abdominal wall inflammation, often triggered by infectious agents. Understanding its immunological mechanisms is crucial for innovative therapies. The regulatory peptide galanin and its receptors (GAL1-3-R) are expressed on various immune cells and play pivotal roles in inflammation. The impact of GAL2/3-R knockout (KO) was assessed in a preclinical peritonitis model, using aged 4% thioglycollate medium (TGM) injected intraperitoneally in GAL2/3-R KO and corresponding WT mice. Comparison to vehicle controls was included to discern treatment-