Topic: CHI3L1

Huntington’s disease (HD) is a genetic neurodegenerative disorder that can result in motor, mood and cognitive symptoms. HD pathophysiology has been linked to neuroinflammation, which is the presence of inflammatory mediators and reactive glial cells in the brain parenchyma. Many signalling pathways likely interact to propagate neuroinflammation and contribute to cell loss. Previous literature indicates that in the anterior cingulate cortex, cell loss and neuroinflammation are correlated with HD mood symptoms. This project gives insight into inflammation-related differential gene expression in

Neurogenesis requires the coordinated interplay between different cell types within the specialized microenvironment of the neurogenic niche. An important role is played by glia which, among their homeostatic roles, also include modulation of neural stem cells and their progeny.We will share and discuss recent molecular, biochemical and pharmacological data supporting an important role of astroglial cells in the modulation of neurogenesis under both physiological and pathological conditions, including aging and neurodegeneration. Particularly, focus will be on the role of astrocytes and their