Topic: Child Abuse

Major depression is a psychiatric disease extremely widespread and the leading cause of disability worldwide. Child abuse, defined as physical, emotional and/or sexual abuse or neglect, is considered as one of the strongest predictors of depression and suicidal behaviors. While the role of the locus-coeruleus noradrenergic system (LC-NE) in the long term effect of early life stress induced depression has been demonstrated in male, its involvement in female is lacking. The aim of this project is to better understand the contribution of LC-NE circuits in early life stress-induced depression in a

Resilience, defined as the ability to positively adapt to stress, is intricately linked to various neurobiological systems, with the noradrenergic (NE) system being a key player. As a primary modulator of the stress response, the NE system also holds significance in brain development, particularly during critical periods. Recent findings in both mice and humans have underscored its role in promoting resilience in the aftermath of stressful events during adulthood. Nonetheless, limited evidence exists regarding its involvement in resilience following child abuse.`To address this inquiry, we emp