Topic: Cholinergic dysfunction

Cholinergic dysfunction contributes to attentional deficits in attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and dementia. Cortical cholinergic inputs are fundamentally linked to attention and phasic acetylcholine (Ach) release causally mediates performance in tasks involving monitoring for cues, cue detection, and cue-directed responding.We investigated the role of muscarinic and nicotinic ACh receptors (mAChRs and nAChRs) in attentional performance by applying systemic manipulations in adult male and female Sprague-Dawley rats during the Signal Detection Task. In this task,

Hippocampal cholinergic neurostimulating peptide (HCNP) was originally discovered from soluble fraction of rat hippocampus, which induces acetylcholine synthesis in the medial septal nucleus. HCNP is aligned at the N-terminal region of 21-kD HCNP precursor protein (HCNP-pp). We reported that HCNP-pp knockout (KO) mice may be an adequate model for cholinergic functional impairment in septo-hippocampal interactions. Here, to encourage drug discovery improving clinical symptom for Alzheimer’s disease we tried to generate a new model mice with cholinergic dysfunction and amyloid pathogenesis. The