Topic: Chrimson

How do we learn about experiences while being removed from the experience itself? One solution involves offline learning via reactivations. Sensory reactivation involves the recurrence of a pattern of neural activity during sleep or quiet waking that previously occurred during a sensory experience. Historically, reactivations have been studied in the hippocampus. However, whether reactivations in sensory cortex depend on local activation of neurons during prior experience is not well understood. We hypothesize that such reactivations in sensory association cortex could be important for learnin

The head direction (HD) system functions as the brain's compass system. HD signals are generated based on vestibular inputs that provide information on self-movement. They are combined with signals that permit orientation coding with respect to external landmarks. Lesion studies point to the Presubiculum as a strong candidate for the integration of HD and landmark signals, but the underlying cellular mechanisms remain to be clarified. Here we show that the presubiculum receives HD signals from the anterior thalamic nucleus (ATN) and visual landmark information from the retrosplenial cortex (RS

The onset of a stimulus, whether sensory or non-sensory, quenches trial-to-trial neural variability. The universality of this phenomenon across brain areas and species implies that it is a fundamental strategy employed by the brain to boost the fidelity of stimulus representation. Multiple network models have attempted to explain this phenomenon via circuit interactions, but a recent alternative theory proposes a much simpler cell-intrinsic mechanism: stimulus onset increases membrane conductance which itself is enough to quench output variability. Although this model can explain all of the ph