Topic: chromatin regulation

Examine how endothelial cells, smooth-muscle cells and pericytes establish vascular networks and sustain organ function through development and aging. Mechanistic sessions connect RNA and chromatin regulation with organelle signalling, mechanotransduction and tissue remodelling. Studies of vascular heterogeneity and inter-organ communication link these processes to malformations and disease, while imaging, multimodal omics and computational methods provide routes toward therapeutic discovery. 10–15 January: Sunday check-in starts at 14:00 and scientific introductions at 19:30; Friday departur

During life, a variety of specialized cells arise to grant the right and timely corrected functions of tissues and organs. Regulation of chromatin in defining specialized genomic regions (e.g. enhancers) plays a key role in developmental transitions from progenitors into cell lineages. These enhancers, properly topologically positioned in 3D space, ultimately guide the transcriptional programs. It is becoming clear that several pathologies converge in differential enhancer usage with respect to physiological situations. However, why some regulatory regions are physiologically preferred, while