Topic: chromatin regulators

Mutations in dozens of chromatin regulators have been implicated in neurodevelopmental disorders. One of these genes is chromodomain helicase DNA binding 2 (CHD2), encoding for a chromatin modifier with largely unknown neuronal functions. In humans, heterozygous loss of function mutations in CHD2 are associated with severe childhood-onset epilepsy, global developmental delay, intellectual disability, and autistic-like features. Here, we characterized the epileptic and behavioral phenotypes of a mouse model with Chd2 haploinsufficiency (Chd2+/m and Chd2m/m mice). Interestingly, we discovered th