Topic: Chromatin remodelling

Chromatin remodelling plays an essential role in development, for instance by controlling gene expression during cell differentiation. Mutations of chromatin remodellers are often implicated in developmental diseases such as CHARGE syndrome, in which a heterozygous mutation of the chromatin remodeller CHD7 is the major driver of the disease. To investigate the role of Chd7 during brain development, we used a dorsal telencephalon-specific Chd7 loss-of-function mouse model and discovered Chd7 acts as a multi-lineage coordinator. Histological analysis of Chd7 mutant mice shows that upon ablation

Drug addiction poses a significant public health challenge, impacting individuals and societies at large. While substantial progress has been made in understanding the neurobiological underpinnings of addiction, certain aspects remain unresolved. Satb2 is a DNA-binding protein involved in gene expression regulation through chromatin remodelling. We propose that it can emerge as a potential player in addiction mechanisms. A Satb2 conditional mutant (cKo) (Satb2 flox/flox::Camk2a-cre) that was generated showed impairment in long-term memory and an absence of this gene in the Cortex and CA1 regio