Topic: chromosome conformation capture

Aging, particularly in the brain, involves impairments in multiple cellular and molecular functions, many of which are regulated at the nucleus. Chromatin structure plays a critical role in the regulation of gene expression and the maintenance of genomic stability. During differentiation, chromosomes acquire their unique topology depending on the cell type that should be kept for a lifetime, but this may deteriorate as we age. However, the effects of aging on the chromatin 3D structure of neurons remain largely unknown. By combining chromosome conformation capture (Hi-C) and microscopy techniq

The mammalian genome is folded into complex structures giving rise to multiple layers of compaction, while still accommodating dynamic and complicated tasks such as replication, transcription, and DNA repair. It is now widely accepted that the 3-dimensional (3D) genome organization plays an important role in both establishing and maintaining stable gene expression patterns, which impacts the development of cell-type identities. The development of chromosome conformation capture (3C) technology has been crucial in the endeavor to understand the organization of the 3D genome, and various structu