Topic: chronic corticosterone

Survival and well-being hinge on an organism's adeptness at evaluating diverse options, considering the costs and benefits before making adaptive decisions. The influence of stress on cognition and reward-related behaviors varies depending on factors such as the duration and type of stressor, as well as intricate interactions between genetic factors and the environment. Stress may either enhance optimal decision-making and reward-related approaches or contribute to cognitive impairments and ineffective coping mechanisms, falling along a spectrum from resilience to vulnerability. The impact of

The increasing prevalence of psychiatric disorders, such as depression, highlights the need to elucidate their underlying neurobiological mechanisms. The lateral habenula (LHb) and its neuronal activity contribute to the pathophysiology of depression when dysfunctional. Among the existing rodent models of depression, chronic corticosterone administration for 3-4 weeks recapitulates relevant behavioural aspects of the disease such as anhedonia and increased passive coping. However, the temporal emergence of these features and the cellular underpinnings remain unclear. Thus, we assessed the emer