Topic: Chronos

Neural computation depends on inter-areal signal transformations, which are determined by the input-output (I/O) functions of individual and networks of neurons. Due to intrinsic neuronal properties and inter-neuronal interactions, networks can show preferences for synaptic inputs in certain frequencies, e.g. in the form of lowpass filtering or resonance [Izhikevich 2003, Cardin et al 2009, Lewis et al 2021, Pike et al 2000]. High-density silicon-probe recordings were made from area V1 and V2 in awake mice. We used optogenetic stimulation (continuous (1s), pulses (5ms), sinusoids) with an opsi

The head direction (HD) system functions as the brain's compass system. HD signals are generated based on vestibular inputs that provide information on self-movement. They are combined with signals that permit orientation coding with respect to external landmarks. Lesion studies point to the Presubiculum as a strong candidate for the integration of HD and landmark signals, but the underlying cellular mechanisms remain to be clarified. Here we show that the presubiculum receives HD signals from the anterior thalamic nucleus (ATN) and visual landmark information from the retrosplenial cortex (RS