Topic: Chx10

The brainstem reticular formation (RF) is key for controlling movements, both at the spinal (e.g., trunk, limbs) and at supra-spinal (e.g., orofacial, ocular) levels. Yet, in this heterogenous structure, the specific contributions of discrete cellular populations to identified unitary actions remain poorly understood. The V2a identity (Chx10-expressing) circumscribes a subgroup of glutamatergic neurons along the rostrocaudal axis of the pontomedullary RF. In the mouse, those located in the gigantocellular reticular nucleus (GRN) were shown to control limb and head-related motor components of o

Which specific ventral spared interneuron populations take part in spinal tissue reorganization after a traumatic injury (TSCI) has not been clarified yet. We hypothesize that these cells could reactivate developmental processes to be able to form new connections, and that this process could help us to characterize them after lesion. qPCR results indicated a potential re-expression of the transcription factor Vsx1, (which in a normal situation is transiently expressed at early embryonic stages in an intermediate V2 interneurons compartment and absent in the adult spinal cord) 2 weeks after TSC