Topic: circadian oscillator

The choroid plexus (ChP) is a highly vascularized non-neural tissue located in the brain ventricles and is responsible for the production of a large part of the cerebrospinal fluid (CSF). In addition, the epithelial cells of the ChP synthesize neurotrophic factors and other signalling molecules into CSF and act as a blood-cerebrospinal fluid barrier. Importantly, ChP cells harbour a robust circadian oscillator that may control ChP function and may play an important role in the circuitry between brain clocks. In this study, we aimed to find out whether the ChP clock is sensitive to a robust imm

Some 320 million years ago, amniotes began to invade our planet's terrestrial niches. These amniote ancestors gave rise to two lineages that have led to today's mammals (synapsids) and sauropsids (reptiles and birds). Mammals and non-avian reptiles are the only vertebrates with a layered cerebral cortex. To which degree their circadian systems share common mechanisms or have unique adaptions in regulating sleep timing and architecture is unknown. Early circadian studies in reptiles lack conclusive interpretations and technologies have since greatly improved. The bearded dragon is an establishe