Topic: circadian regulation

Disruption of circadian regulation, particularly during the early developmental stages (EDS), can have deleterious, long-lasting effects. Previous studies have shown that melatonin is involved and that susceptibility to chronodisruption in rats is sex-dependent. Our aim was to investigate the effect of chronodisruption via constant light (LL) during EDS on the clock in the suprachiasmatic nucleus (SCN) of male and female mice naturally deficient in melatonin. We used PER2::LUC knock-in mice, which allows monitoring of clock function in organotypic explants ex vivo. First, we showed that the SC

Vasopressin (VP) production in the Suprachiasmatic Nucleus (SCN) is influenced by the rhythm of clock genes and the light-dark cycle. The circadian production and release of VP from SCN terminals is one of the core signals via which the biological clock imposes its rhythm on its target structures. It is a critical element in the circadian regulation of corticosterone secretion, reproductive cycle, and metabolism in rodents. All these circadian variables are regulated within very narrow boundaries at a specific time of the day, indicating the need for an elaborate feedback system to inform the