Topic: circuit hyperexcitability

Aims: Nuclear pore complex proteins (Nups) play critical roles in cell type-specific gene regulation by orchestrating lineage specification and maintenance of cellular state. However, their roles in adult brain remain largely elusive, especially in post-mitotic functional neurons. Accurate spatio-temporal regulation of neuronal gene programs is vital for neuronal plasticity and ultimately for learning and memory. We hypothesize that Nups play critical roles in neuronal plasticity and cognition through gene regulation. Methods: To address the importance of Nups for cognition and memory, we cond

Early changes in network activity serve as distinctive hallmarks in tauopathies such as Alzheimer’s Disease and Frontotemporal Dementia. Decades before the onset of cognitive decline, many patients experience seizures which exacerbate the condition. Despite the recognised etiological overlaps between tauopathies and epilepsies, the relationship between tau and the development of circuit hyperexcitability is unclear and needs further investigation. Using wireless EEG to record intrahippocampal local field potentials (LFP), we characterised early biophysical alterations within the hippocampus of