Topic: circuit tracing

The ability to flexibly adjust our decision making is crucial for navigating a complex world where optimal decisions depend on the current context. Crucially, it is thought that the bidirectional connection of the prefrontal cortex (PFC) and hippocampus (HPC) through the nucleus reuniens of the thalamus (nRE) is vital for coordinating context-dependent decisions. However, little is known about how interaction of PFC and HPC via nRE guides behaviour. To address this, we used a cued T-maze in mice, where a cue predicts a distal reward location, combined with circuit-specific modulation of nRE. U