Topic: Clemastine

The neural basis of abnormal social behavior in autism spectrum disorder (ASD) remains incompletely understood and previous studies has highlighted that altered myelination could be involved in the pathophysiology of ASD. We have characterized the myelination process during development in the cntnap2-/- mouse model of ASD. We observed that oligodendrocyte differentiation and myelination are transiently impaired during cortical development in cntnap2-/- mice. Thus, we observed a reduction in myelinated fibers, the number of nodes of Ranvier and the proportion of mature oligodendrocytes in somat

Neonatal hypoxic ischemia (HI) causes motor impairment affecting daily activity. Rehabilitation is frequently implemented to improve motor performance, but its effects are often insufficient for acquiring fine motor coordination. Recently, myelin plasticity has been pointed out necessary for improving motor skills. However, the significance of myelination for motor improvement after HI remains unclear.To address this issue, we investigated the effect of rehabilitation exercise on myelination in a neonatal HI rat model. We then examined the effectiveness of pharmacological promotion of myelinat