Topic: closed-loop optogenetic stimulation

Neuronal oscillations are a prominent feature of motor cortical local field potentials (LFPs) and abnormalities in oscillatory activity have been linked to several disorders. Theta-modulated gamma-frequency pulses of alternating current stimulation modulate motor learning in humans, however, it is unclear how these frequencies modulate motor cortical activity at the cellular microcircuit level. Here, we aimed to develop a method of bidirectionally modulating theta and gamma coupled oscillations in the motor cortex using closed-loop optogenetic stimulation of excitatory RBP4-Cre (retinol-bindin

Disrupted neural oscillations and memory are common features of Alzheimer's disease (AD). Our previous studies have demonstrated the potential to restore theta oscillations by utilizing LFP-guided closed-loop optogenetic stimulation of local parvalbumin-positive (PV+) interneurons in the CA1 region of the hippocampus in APP/PS1dE9 mice. Furthermore, employing the same protocol, we successfully enhanced the performance of transgenic mice in a spatial memory tests. Based on these findings, our objective is to investigate the impact of PV+ stimulation on circuit function within the CA1 region. To