Topic: colony formation

Glioblastoma multiforme (GBM) is a highly malignant brain tumor with poor prognosis after conventional treatment. Therefore, potential treatment strategies and novel therapeutic targets have gained increased attention. Vanilla planifolia is a source of vanilla flavoring due to its high vanillin content, and several studies have shown its antitumor activity. Our data revealed that an ethanol extract of vanilla planifolia stem (VAS) at 200 ng/μl significantly reduced cell viability and colony formation in GBM cells. VAS also induced autophagy, as shown by MAP1LC3 cleavage. Further RNA-seq analys

The mechanisms underlying the emergence of a social organization in mice are mainly studied in unisex male colonies. In isogenic male mice groups, we previously showed that sociability trait predicts rank attainment in social hierarchy whereas differences in anxiety between highest and lowest ranked individuals appears after rank establishment (Battivelli et al. 2024).Here we show that isogenic female mice grouped by four rapidly form enduring social hierarchy, that can be analysed using a precedence test based on encounters within a plastic tube from which lower-ranked individuals come out ba