Seminar · Neuroimmunology
Neuro-Immune Coupling: How the Immune System Sculpts Brain Circuitry
Beth Stevens · Boston Children's Hospital/Harvard Medical School, Boston, MA, USA
Mon, Jun 21, 2021 · 15:00 UTC
In this lecture, Dr Stevens will discuss recent work that implicates brain immune cells, called microglia, in sculpting of synaptic connections during development and their relevance to autism, schizophrenia and other brain disorders. Her recent work revealed a key role for microglia and a group of immune related molecules called complement in normal developmental synaptic pruning, a normal process required to establish precise brain wiring. Emerging evidence suggests aberrant regulation of this pruning pathway may contribute to synaptic and cognitive dysfunction in a host of brain disorders,