Topic: Compound Action Potential

Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disease characterized by the absence of the cytoskeletal protein dystrophin (Dp427). Short isoforms, such as Dp116 in myelinating Schwann cells (SCs), exist in specific cell types. In SCs, Dp116 binds to the dystrophin-associated glycoprotein complex (DGC), which crucially contributes to myelin integrity and fiber conduction properties. Our prior research on the sciatic nerve (SN) of wild-type and mdx mice, a DMD animal model lacking Dp427, revealed a significant decrease in all myelin protein levels, indicating compromised myelin

Neural interfaces to peripheral nerves are increasingly employed for basic research, neuroprosthetics, and bioelectronic medicine (‘electroceuticals’). We previously established a pipeline for hybrid electromagnetic-electrophysiology modeling of nerve stimulation on the o2S2PARC platform for collaborative, FAIR, and reproducible computational neurosciences. It leverages histological data to generate a detailed anatomical model of the nerve microstructure and to functionalize it with populations of fiber neuro-dynamics models (myelinated/unmyelinated, statistical distributions of fiber types an