Topic: compulsive alcohol self-administration

Sex is an important factor in the progression and treatment of alcohol addiction, and therapeutic approaches may have to be tailored to potential sex differences. This highlights the importance of understanding sex differences in behaviors that reflect key elements of clinical alcohol addiction, such as compulsive use.Large populations of genetically heterogeneous male and female Wistar rats were tested in an established model of compulsive alcohol self-administration, operationalized as alcohol responding despite contingent foot shock punishment. We also tested baseline alcohol self-administr

Adolescent adverse social experiences can evoke long-lasting neurobiological changes, thereby affecting subsequent behaviors including propensity to develop alcohol use disorder. The aim of this study was to explore the long- term consequences of early social isolation on alcohol consumption and motivation for alcohol.Here, we exposed male and female Wistar rats to social stress during adolescence and investigated the consequences on alcohol-related behaviors in adulthood. Adolescent rats (p21-60) were exposed to social isolation (SI) that was achieved by single housing rats throughout adolesc