Topic: conditional knockout

Cadherin-13 (CDH13) is a member of the cadherin superfamily, which consists of cell-adhesion molecules. CDH13 is involved in the regulation of synapse formation and maintenance, as well as serotonergic neuron development. Serotonergic neurons mainly originate from the raphe nuclei in the hindbrain. In mice, CDH13 is first detected roughly halfway through the embryonic development in the hindbrain. Studies suggest a role of CDH13 in the pathophysiology of neurodevelopmental disorders. After previously investigating the role of CDH13 during embryonic development, we now aimed for the analysis of

Early life adversity (ELA), defined as an adverse experience during critical periods in brain development, is a risk factor for neurodevelopmental and psychiatric disorders. The major effector molecules of stress are glucocorticoids (GCs), which by binding to glucocorticoid receptors (GRs) regulate several biological processes in the brain and the body. So far, little is known about the effects of ELA on a subtype of glial cells, named oligodendrocyte precursor cells (OPCs) or NG2-glia. To investigate how GCs can affect the molecular signature of the NG2-glia and impact the behavioral phenotyp

Orexin binds G-protein-coupled receptors, orexin receptor 1 (Ox1R) and 2 (Ox2R). These receptors modulate diverse brain functions, such as sleep and metabolism, with their wide expression throughout the brain. Previous in vitro studies have found that Ox2R works in both Gq and Gi-coupled signaling pathways, indicating excitatory and inhibitory functions respectively. In vivo studies, however, the inhibitory role has yet to be discerned, whereas the excitatory function has been elucidated in numerous reports. Consequently, Ox2R is predominantly recognized for eliciting only excitatory signals i