Topic: Conditional Place Preference

Drug addiction poses a significant public health challenge, impacting individuals and societies at large. While substantial progress has been made in understanding the neurobiological underpinnings of addiction, certain aspects remain unresolved. Satb2 is a DNA-binding protein involved in gene expression regulation through chromatin remodelling. We propose that it can emerge as a potential player in addiction mechanisms. A Satb2 conditional mutant (cKo) (Satb2 flox/flox::Camk2a-cre) that was generated showed impairment in long-term memory and an absence of this gene in the Cortex and CA1 regio

Soft touch stimulation can be decoded as positive tactile information, though little is known about the neurobiological brain mechanisms involved. The Subparafascicular Thalamic Nucleus (SPF) receives input from the spinal dorsal horn and sends projections to brain regions processing the affective component of pain such as the amygdala and insular cortex. Recent studies have suggested that SPF act as a gate of threatening cues and is important for aversive learning (Kang et al., Cell Reports, 2022). Here, we investigated if the SPF is also involved in positive aspects of sensory processing, su