Cone photoreceptors

Photoreceptors, the light sensors of the retina, come in two varieties: the light-sensitive rod photoreceptors, which are responsible for night vision, and the cone photoreceptors, which operate at higher light intensities and are responsible for daylight and color vision. These different tasks require specific morphological and molecular adaptations of rod and cone photoreceptors in the processes of transduction and transmission of light signals. Here we present the first deep proteome resource of mouse rod and cone photoreceptors to our knowledge. We have established a method using fluoresce

Understanding the retina in health and disease is a key issue for neuroscience and neuroengineering applications such as retinal prostheses. Although the processing of visual information in the healthy retina has been studied in detail, no comprehensive computational model exists that captures the many cell-level and network-level biophysical changes common to retinal degenerative diseases. To address this challenge, we developed a biophysically detailed model of the retinal circuitry and simulated the network-level response to both light and electrical stimulation. The model included 11,138 c

…signal processing in the retina: rod photoreceptors must transduce single photon absorptions with high fidelity, single photon signals in photoreceptors, which are only 0.03 – 0.1 mV, mus

Understanding the retina in health and disease is a key issue for neuroscience and neuroengineering applications such as retinal prostheses. Although the processing of visual information in the healthy retina has been studied in detail, no comprehensive computational model exists that captures the many cell-level and network-level biophysical changes common to retinal degenerative diseases. To address this challenge, we developed a biophysically detailed model of the retinal circuitry and simulated the network-level response to both light and electrical stimulation. The model included 11,138 c

…the first neuron of the visual system, photoreceptors are vital for photoreception and transmission of visual signals. I am particularly interested in cone

…renewed look at the spectral tuning of cone photoreceptors in the live eye. We find that already cones optimally rotate natural colour space in a PCA-like fashion to disambiguate greyscale from "colour" information. We then follow this signal through the retinal layers and ultimately into the brain to explore the major spectral computations performed by the visual system at its co