Topic: contextual memory consolidation

Sparsely distributed hippocampal CA1 engram cells, activated at the time of learning and receiving input from the CA3, are critical to contextual memory consolidation. This manifests as an augmentation of synaptic connectivity between these hippocampal subfields. Enhanced green fluorescent protein (GFP) reconstitution across synaptic partners (eGRASP) facilitates structural and electrophysiological analysis of input-specific synapses between engram cells. However, the protein landscape shaping and maintaining this enhanced engram synaptic connectivity remains unknown. Global proteomic analysis

Rapid eye movement (REM, also called paradoxical) sleep correlates with enhanced cellular activity in region-specific thalamo-cortical circuits and subcortical structures including the hippocampus, midbrain or hypothalamus. This REM sleep specific neuronal activity is hypothesized to promote structural plasticity and provide a window for the consolidation of contextual and emotional memories previously acquired during wakefulness, yet the underlying mechanism remains unclear.Amongst the cortical structures, the activity of neurons located in the retrosplenial cortex (RSC) is increased during R