Topic: cortical pyramidal cells

A myriad of pathological changes associated with epilepsy, including the loss of specific cell types, improper expression of individual ion channels, and synaptic sprouting, can be recast as decreases in cell and circuit heterogeneity. In recent experimental work, we demonstrated that biophysical diversity is a key characteristic of human cortical pyramidal cells, and past theoretical work has shown that neuronal heterogeneity improves a neural circuit’s ability to encode information. Viewed alongside the fact that seizure is an information-poor brain state, these findings motivate the hypothe

Low-intensity ultrasound neuromodulation is a rapidly emerging technology due to its non-invasiveness and millimeter-scale precision. Despite numerous experimental settings demonstrating that ultrasonic waves can modulate the neural activity in different brain areas, the interaction between the ultrasonic source and the neuronal tissue is still not fully understood. Several underlying mechanisms have already been proposed to partially explain the interaction between ultrasound and neurons, including mechanosensitivity, flexoelectricity, membrane displacement, and thermodynamic effects. Unders