Topic: cortico-cerebellar loops

A recent surge of experimental evidence points towards a significant role of the cerebellum in the development and maintenance of neocortical states through cortico-cerebellar loops. Notably, the re- sulting positive feedback loop is not limited to the motor domain to which the cerebellum is classically associated but has been shown to extend to various cognitive processes. However, it remains unclear what functional principles may underlie these cerebro-cerebellar loops. Here we model a neocortical area as a recurrent neural network which projects to, and receives from, a cerebellar feedforwa

Recent evidence suggests that the cerebellar hemispheres are in a unique position to contribute to motor planning via cortico-cerebellar loops. However, it is unknown how the dynamics of preparatory activity relate to the functional parcellation of the cerebellar cortex. We used mesoscale widefield calcium imaging to study molecular layer interneuron and Purkinje cell dendritic Ca2+ activity in Simplex, Crus I and Crus II during a targeted lick-interception task. We identified independent spatial sources of Ca2+ activity in interneurons and Purkinje cell dendrites using non-negative matrix fac