Topic: Cortico-hippocampal interactions

Cortico-hippocampal interactions during hippocampal sharp-wave ripples (SPW-Rs) play a crucial role in memory consolidation. Hippocampal-dependent memories undergo replay during SPW-Rs, facilitating coordinated ensemble reactivation in the neocortex. This orchestrated mechanism is essential for transferring memory traces from the hippocampus to long-term storage in the neocortex. Following memory consolidation in the neocortex, it is hypothesized that downstream neuronal ensembles are stabilized in diverse cortical regions. The stability of neuronal ensembles across several months has not been

The ventral midline thalamic reuniens/rhomboid (ReRh) nuclei, have been implicated in contextual and spatial memory persistence. Based on its bidirectional connections with the medial prefrontal cortex (mPFC) and hippocampus, the ReRh serves as a critical relay in the transfer of information between both structures, holding a key position to regulate cortico-hippocampal interactions. This interplay is not only essential for systemic consolidation of spatial and contextual memories but might also be required in spatial working memory. Based on the idea that interactions crucial for subsequent s